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John D Phillips Selected Research

Hepatic Porphyrias (Hepatic Porphyria)

11/2019Heme biosynthesis and the porphyrias.
11/2019International Porphyria Molecular Diagnostic Collaborative: an evidence-based database of verified pathogenic and benign variants for the porphyrias.
10/2017Acute hepatic porphyrias: Recommendations for evaluation and long-term management.
5/2014RNAi-mediated silencing of hepatic Alas1 effectively prevents and treats the induced acute attacks in acute intermittent porphyria mice.

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John D Phillips Research Topics

Disease

12Porphyrias (Porphyria)
01/2022 - 01/2006
8Acute Intermittent Porphyria (Porphyria, Acute)
01/2020 - 01/2006
7Erythropoietic Protoporphyria
01/2022 - 04/2013
6Porphyria Cutanea Tarda
11/2019 - 11/2005
5Hemochromatosis (Bronze Diabetes)
01/2016 - 10/2002
4Fibrosis (Cirrhosis)
01/2022 - 01/2006
4Hepatic Porphyrias (Hepatic Porphyria)
11/2019 - 05/2014
3Neoplasms (Cancer)
01/2022 - 01/2020
3Anemia
12/2021 - 10/2014
3Hereditary Coproporphyria (Coproporphyrinogen Oxidase Deficiency)
11/2019 - 01/2006
2Inflammation (Inflammations)
01/2022 - 12/2021
2Variegate Porphyria (Protoporphyrinogen Oxidase Deficiency)
11/2019 - 11/2019
2Liver Diseases (Liver Disease)
09/2018 - 04/2013
1Myocardial Ischemia (Ischemic Heart Diseases)
01/2022
1Myocardial Reperfusion Injury
01/2022
1Reperfusion Injury
01/2022
1Infarction (Infarctions)
01/2022
1COVID-19
01/2021
1Inborn Genetic Diseases (Disease, Hereditary)
01/2020
1Ataxia (Dyssynergia)
01/2019
1Fatty Liver
08/2018
1Hyperferritinemia
08/2018
1Acute Erythroblastic Leukemia (Erythroleukemia)
01/2017
1Autoimmune Diseases (Autoimmune Disease)
01/2016
1Lead Poisoning (Poisoning, Lead)
12/2015
1Iron Overload
08/2015
1Pain (Aches)
07/2015
1Hyperplasia
06/2015
1Coloboma (Colobomas)
01/2012
1Methemoglobinemia
04/2011
1Cyanosis
04/2011
1Congenital Methemoglobinemia
04/2011
1Infections
01/2011
1Erythropoietic Porphyria (Congenital Erythropoietic Porphyria)
03/2007
1Thalassemia
03/2007
1Thrombocytopenia (Thrombopenia)
03/2007
1Photosensitivity Disorders (Photodermatitis)
03/2007
1beta-Thalassemia (Cooley's Anemia)
03/2007
1Hepatoerythropoietic Porphyria
02/2007
1X-linked sideroblastic anemia
07/2006
1Hepatitis C
01/2006

Drug/Important Bio-Agent (IBA)

12Heme (Haem)IBA
12/2021 - 07/2006
10IronIBA
12/2021 - 10/2002
5EnzymesIBA
11/2019 - 07/2006
5Uroporphyrinogen Decarboxylase (Uroporphyrinogen III Decarboxylase)IBA
11/2019 - 10/2002
5protoporphyrin IXIBA
09/2018 - 04/2013
4Proteins (Proteins, Gene)FDA Link
01/2022 - 01/2020
3Acute Hepatic PorphyriaIBA
01/2022 - 05/2014
3Hydroxymethylbilane Synthase (Porphobilinogen Deaminase)IBA
11/2019 - 01/2019
3Aminolevulinic Acid (Levulan)FDA Link
09/2018 - 11/2005
3PorphyrinsIBA
09/2018 - 10/2014
2Coproporphyrinogen Oxidase (Coproporphyrinogen III Oxidases)IBA
11/2019 - 01/2006
2Hydro-Lyases (Dehydratases)IBA
11/2019 - 01/2006
2AcidsIBA
01/2019 - 01/2006
2PorphobilinogenIBA
01/2019 - 01/2006
2Ferrochelatase (Heme Synthetase)IBA
09/2018 - 04/2013
2Messenger RNA (mRNA)IBA
01/2016 - 04/2005
2Polychlorinated Biphenyls (PCBs)IBA
03/2007 - 10/2002
1SolutionsIBA
01/2022
1Subfamily B ATP Binding Cassette TransporterIBA
01/2022
1CytokinesIBA
01/2022
1itaconic acidIBA
12/2021
1TetrapyrrolesIBA
12/2021
1LigandsIBA
01/2020
1HLA Antigens (Human Leukocyte Antigens)IBA
01/2020
1T-Cell Antigen Receptors (T-Cell Receptor)IBA
01/2020
1Vitamin B Complex (B Vitamins)IBA
01/2020
1Protoporphyrinogen Oxidase (Protox)IBA
11/2019
1Isoniazid (Ftivazide)FDA LinkGeneric
11/2019
1Aspartate Aminotransferases (Aspartate Transaminase)IBA
08/2018
1Alanine Transaminase (SGPT)IBA
08/2018
1Small Interfering RNA (siRNA)IBA
01/2017
1Antigen Receptors (Antigen Receptor)IBA
01/2016
1AcyltransferasesIBA
01/2016
1MetalsIBA
12/2015
1zinc protoporphyrinIBA
12/2015
1Transferrin Receptors (Transferrin Receptor)IBA
08/2015
1metal transporting protein 1 (ferroportin)IBA
08/2015
1Melanocyte-Stimulating Hormones (MSH)IBA
07/2015
1afamelanotideIBA
07/2015
1Hemin (Panhematin)FDA Link
06/2015
1hydroxymethylbilaneIBA
06/2015
1protoporphyrinogen (protoporphyrinogen IX)IBA
10/2014
15-Aminolevulinate SynthetaseIBA
04/2013
1ATP-Binding Cassette Transporters (ABC Transporters)IBA
01/2012
1MorpholinosIBA
01/2012
1Adenosine Triphosphate (ATP)IBA
01/2012
1CytochromesIBA
12/2011
1Cytochrome P-450 CYP1A2 (CYP1A2)IBA
12/2011
1rat Cyb5R3 proteinIBA
04/2011
1HepcidinsIBA
12/2008
1Uroporphyrinogen III Synthetase (Uroporphyrinogen-III Synthase)IBA
03/2007
1Trans-Activators (Trans-Acting Factor)IBA
03/2007
1GlobinsIBA
03/2007
1uroporphyrin IIBA
03/2007

Therapy/Procedure

3Therapeutics
01/2022 - 05/2014
2Liver Transplantation
06/2015 - 01/2006
1Immunotherapy
01/2020
1Appendectomy
12/2014
1Cholecystectomy
12/2014